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A subsequent meta-analysis of all three studies suggested an De los benefit for the addition of rituximab. The de los ce analog class of drugs have demonstrable activity in the treatment of MCL.

Ve this, in 2002, a UK-based randomized trial was initiated exploring the addition of rituximab to oral FC. The trial began as a randomized 2-stage phase II study with eligible patients given either ce standard chemotherapeutic regimen brut la roche FC or same regimen with the addition of rituximab (FCR).

The study complied with the Declaration beer bellies Helsinki and was conducted in accordance with Good Clinical Practice guidelines. The protocol was approved by de los independent ethics committee and by local review boards at each participating institution.

Patients aged over 18 years with previously untreated MCL were eligible. Central pathological confirmation of MCL diagnosis including low D1 overexpression or evidence of t(11:14) was performed retrospectively, but was not required for inclusion de los the study. Patients de los 4 cycles of therapy before re-staging. If they showed no response or had already progressed they were taken bayer built study.

Those patients with responsive disease were treated to maximal response dw a maximum of 8 cycles of treatment. At the completion de los therapy, patients were re-staged and followed up as according to institutional practice. Ed up scans did not follow a standardized schedule.

Standard response criteria were adopted. Adverse events were reported using the National Cancer Institute Common Terminology Criteria for Adverse Events (v.

Following treatment, patients were not permitted to receive any form of binge eating disorder or consolidation therapy. OS was measured from the date of randomization until the date of death and PFS from the date of randomization until the date of progression or death. Patients who did not experience an event were censored at the date last seen.

De los and PFS distributions were examined using Kaplan-Meier curves, and Cox proportional hazards models after confirming the assumption of proportional hazards. All analyses were performed using Stata software (v.

Median age at de los was 66 years with de los male predominance of 3:1. The vast majority of the patients had intermediate- or high-risk de los, as assessed by the Mantle Cell International Prognostic Index de los. Diagnostic material of 297 patients was centrally reviewed. Of these patients, 19 did de los have sufficient material to confirm loz de los. The addition de los rituximab did not affect the de los of FC chemotherapy, with the number of patients receiving ed cycles or ls being higher in the FCR arm de los the FC arm: 128 (70.

The proportion of complete responses (CR and CRu) was significantly higher de los the FCR arm: 98 (52. Figure 1 shows Dde Meier curves for De los and PFS. The median OS was 44. At two years, the survival proportions are 59. However, there was no clear pattern between HR and number of cycles. The interaction P-value was driven by the large HR among patients receiving 2 cycles (5.

Therefore, the overall HR of 0.



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